A postdoctoral fellow to study antibody-mediated destruction of blood cells
The Department of Experimental Immunohematology is looking for a highly motivated postdoctoral fellow to investigate how antibodies recruit accessory pattern recognition molecules such as C-Reactive protein stimulate destruction of blood cells. In addition, considerable focus will also be given to B cells, their antibody repertoire analysis, and regulation of antibody glycosylation on the single cell level. The work is based on work from our group indicating that clinical significance of auto- and allo-antibodies are not dependent on the sheer presence and magnitude of these antibodies, but also controlled regulation of their glycosylation affecting Fc-receptor and complement activity, as well as general inflammatory status of the patient.
We offer challenging research topics that can be tackled with state of the art technologies. The research will performed within a multi-disciplinary and enthusiastic team, consisting of senior research teams, other post-docs, PhD students and technicians.
Where you will work:
The Research Division of Sanquin Blood Supply Foundation (Amsterdam, The Netherlands) performs research relating to blood transfusion medicine in its broadest sense and is an integrated division with approximately 250 researchers. The research is performed within the context of the Landsteiner Laboratory of the Academic Medical Center of the University of Amsterdam, and collaborating strongly with Sanquin Diagnostics. The spear points of our research involves, but is not limited to, immunological response against blood group antigens, immune regulation, antigen presentation, T-cell responses, blood coagulation, phagocyte and cell biology. The post-doc will be embedded in a research group presently consisting of 8 PhD students, 4 technicians, one post-doc, and two senior scientists. Part of this project will also carried out together with PhD student
We are looking for:
- enthusiastic candidate with PhD degree in a relevant field (e.g. Immunology or molecular biology / B cell biology / knowledge of eukaryotic glycosylation machinery and or mass-spectrometry is a pre);
- interest and background in Cellular Immunology and Molecular Biology, B cells antibodies and their receptors;
- an independent scientist that can function well as part of a team;
- good knowledge of spoken and written English is required;
- excellent (potential) published track-track record in one or more of the fields above.
- salary and employment conditions are in accordance with CAO Sanquin (Collective Terms of Agreement);
- a temporary appointment for a period of 3 years;
- a 36-hour-week;
- working hours will be determined by mutual agreement;
- reimbursement of travel expenses in accordance with CAO;
- 8,33% year-end;
- 201 vacation hours with full time employment.
For additional information on the PhD function in the Department of Immunohematology Experimental please contact dr. G. Vidarsson, tel. +31 6120 22321.
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