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PhD position Fluorine MRI of cardiac inflammation
AMC Medical Research supports financiers, project leaders and coworkers on clear, effective and Legal execution of medical research within the Academic Medical Center (AMC) third parties financed. It contains advising and guidance on project preparations, project services and staffing management.
The Preclinical and Translational MRI group, headed by prof. dr. ir. Gustav Strijkers, has the ambition to develop novel quantitative and comprehensive MRI technology. Application areas include cardiovascular diseases, oncology, and neuromuscular disorders. The research is translational (from mouse to human) and has strong links to the Radiology department. Core facility of the group is a new laboratory equipped with a 7 Tesla preclinical MRI scanner for animal research.
The Preclinical and Translational MRI group of the Department of Biomedical Engineering and Physics of the Academic Medical Center (AMC) in Amsterdam is hiring a PhD candidate for a project on fluorine MRI of cardiac inflammation. Inflammation is a key player in various heart diseases. Therefore, a noninvasive imaging method to provide information on the location, amount and dynamics of myocardial inflammation can significantly improve the patient's outcome. Fluorine (19F) magnetic resonance imaging (MRI) of fluorine-containing nanoparticles that home to sites of inflammation holds great promise for specific and quantitative assessment of cardiac inflammation. The PhD project involves the application of nanoparticles to characterize cardiac inflammation in a mouse model of myocardial infarction using multimodal 19F-MRI and ultrasound imaging. To overcome the challenges of imaging of the beating mouse heart, novel scan acceleration technology will be developed to improve sensitivity and decrease 19F-MRI scan times.
We are looking for a candidate with an MSc degree in Biomedical Engineering, Biomedical Sciences, or similar. A strong interest and preferably experience with preclinical research is necessary. An article 9 certificate of the Experiments on Animals Act (Dutch: Wet op de Dierproeven) is a prerequisite. We are looking for a positively minded scientist with verbal and written skills in English, motivated to learn new approaches and ready to work hard to build a scientific career in translational medicine.
Salary and Benefits:
Working at AMC means working in an inspiring and professional environment in which developing one`s talents and skills is encouraged. We offer a salary in line with the Collective Labor Agreement for University Medical Centers in the Netherlands (CAO UMC) with a range of added fringe benefits, such as an annual bonus of 8.3 %, holiday allowance, collective discounted rates for a number of insurances, an attractive bicycle scheme and/or public transport allowance, and free parking. The position is for 4 years. The maximum gross full-time monthly salary for this position, depending on qualifications and experience, is € 2.874,- (scale OIO)
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