PhD student, Adaptive Immunity Lab, Department of Hematopoiesis, Amsterdam 36h
MK 37-14 EXTEW
About the position:
Sanquin Research performs basic, applied and clinical research in the field of blood and blood transfusion. At the Adaptive Immunity Laboratory, which is part of the Department of Hematopoiesis, we investigate the mechanism by which the immune system generates effector T cells and antibody responses that are required for defense against invading pathogens, but that may also develop during allo-immunisation. We also examine the influence of these effector T cells on the formation of new blood cells in the bone marrow, with the aim to identify the cellular and molecular mechanisms by which the immune system regulates blood cell formation during infections. Knowledge obtained from these fundamental research lines will provide insight into the consequences of (chronic) inflammation, such as the development of anemia. Moreover, this information can also be applied for the development of new therapies and the improvement of the cell transfusion products that Sanquin generates for clinical applications.
About the department:
Patients that frequently receive blood transfusions develop the risk of developing allo-reactive antibodies due to mismatches in blood group antigens. This can severely complicate patient management, since the presence of multiple allo-antibodies may lead to the situation that no or only very few donor units are available. Furthermore, when allo-antibodies are not recognized this can lead to hemolytic transfusion reactions. It is currently unclear what molecular interactions drive allogeneic B and T cell responses to blood group antigens. In this project, we will develop novel in vivo models in mice that adequately represent the situation in human blood transfusions with the aim to advance the development of novel strategies to prevent or inhibit such responses. We will therefore collaborate closely with the Department of Experimental Immunohematology at Sanquin and the Department of Hematology from the AMC. We are now looking for a highly motivated PhD student with a keen interest in cellular immunology. The candidate will set up the in vivo blood transfusion models and explore the role of T cell costimulation in the induction of alloreactive immune responses following transfusion. Analytical support by a research technician will be available for the project. This position will lead to the generation and defense of a PhD thesis.
We are looking for:
A highly motivated candidate with a keen interest in cellular immunology;
An MSc. degree in medical or biomedical sciences and practical experience in immunology or cellular biology; having obtained a certificate for conducting animal experiments (#Article 9#) ish ighly recommended;
Decent knowledge of the English language, due to the international character of our research team
- a challenging research position in a multidisciplinary and highly motivated research team;
- salary and conditions are conform CAO Sanquin;
- a 36-hour-week;
- reimbursement of travel expenses;
- a temporary appointment for a period of 4 years;
- working hours are fixed by mutual agreement;
- 8,33% year-end;
- by full-time employment 201 vacation hours.
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