Sanquin Bloedvoorziening voorziet in de behoefte aan bloed en bloedproducten in Nederland. In feite staan wij tussen donor en patiënt. Om deze verantwoordelijke taak goed te kunnen blijven vervullen, zijn we altijd op zoek naar betrokken en gemotiveerd talent. Je zal bijdragen aan een unieke organisatie die een internationale voortrekkersrol vervult dankzij de combinatie van medische, farmaceutische en wetenschappelijke kennis in één innovatieve onderneming. Sanquin Bloedvoorziening is op zoek naar een:
PhD student, dept of Blood Cell Research, Amsterdam
fulltime (36 uur) |
MK 21-14 EXTEW 2
Project title: Standardized allogeneic platelet-rich-plasma (PRP) for improved wound healing in acute and chronic wounds. The vacancy is for a PhD student (4 y) that will work based at the Department of Blood Cell Research on a collaborative project leaded by Dr. D. de Korte (Product and Process Development/Blood Transfusion Technology/Sanquin) and Prof. Dr. E. Middelkoop (Professor of Skin Regeneration and Wound Healing#VUMC), under daily supervision of Dr. L. Gutiérrez (Blood Cell Research#Sanquin). Specific parts of the project will be carried out at the facilities of the Association of Dutch Burn Centers in Beverwijk. The project consists on the standardization and optimization of PRP allogeneic products for the treatment of acute and chronic wounds on patients, as an alternative to the current procedures that use autologous PRP. The two major groups requiring wound healing treatments are burn and diabetes patients, and autologous PRP is subject to variation due to the underlying pathological condition, as well as by the use of various preparation methods. Sofar, the mechanism of action for PRP is unknown. In order to study this, there is demand for a standardized (allogeneic) PRP product in wound healing management. The PhD student will test different PRP product compositions and individual components, as well as application forms (gel, fluid, lysate, etc), in in vitro models (human cell and skin tissue culture) where we can study their effect on migration, proliferation and burn wound healing in relation to the growth factor and specific protein content.
Afterwards, a selection of PRP product compositions, individual components and application forms will be tested in vivo using two animal models: diabetic mice and pigs, where wound healing will be studied. The main goal of the project is to acquire detailed knowledge about the optimal composition and the application form of PRP allogeneic products with the purpose of improving current protocols of acute and chronic wound healing.
You will work in a multidisciplinary international team that focuses on the biology of platelets (dr. Laura Gutiérrez) in health and disease. This team is embedded in the Department of Blood Cell Research (dr. Timo van den Berg), where 35-40 colleagues (post-docs, PhD students and technicians) are studying various aspects of different blood cell types in the context of disease. The research program benefits from the state-of-the-art research facilities at Sanquin, which include facilities for sequencing, molecular cell biology, proteomics and in vivo biomedical studies.
For more information see:
We are looking for:
We are looking for a highly motivated candidate who holds a masters degree in (Bio)Medical Sciences. The candidate must have strong intellectual and communication skills, in addition to experience and/or interest in cell biology, animal experimentation (art. 9 certificate) and translational research.
- salary and conditions are in accordance with CAO Sanquin;
- a temporary position for the duration of 4 years (PhD);
- a 36-hour-week;
- 8,33% year-end;
- 201 vacation hours with full-time employment
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