Sanquin Bloedvoorziening voorziet in de behoefte aan bloed en bloedproducten in Nederland. In feite staan wij tussen donor en patiënt. Om deze verantwoordelijke taak goed te kunnen blijven vervullen, zijn we altijd op zoek naar betrokken en gemotiveerd talent. Je zal bijdragen aan een unieke organisatie die een internationale voortrekkersrol vervult dankzij de combinatie van medische, farmaceutische en wetenschappelijke kennis in één innovatieve onderneming. Sanquin Bloedvoorziening is op zoek naar een:
PhD student,dept of Plasma Proteins and Transfusion Medicine, Amsterdam
MK 35-14 EXTW
Blood platelets are essential in control of bleeding and repair of vascular injury. Decreased platelet counts (thrombocytopenias) occur in patients with congenital platelet disorders and after myelosuppresive chemotherapy or trauma. Transfusion of platelet concentrates provides the najor therapy for these disorders. The main objective of the current project is to investigate the role of surface sialic acid on platelet function and and platelet storage, with emphasis on sialylation of glycoprotein Ib#. In the first part of the project we will study the mechanism of sialidase-induced loss of glycoprotein Ib# in human platelet concentrates using mass spectrometry approaches. It is well-established that patients with immune thrombocytopenia (ITP) have circulating antibodies directed towards glycoprotein Ib#/IX and glycoprotein IIb/IIIa. We and others have shown that removal of sialic acid promotes binding of auto-antibodies to these platelet surface receptors. In the second part of this project we will determine whether removal of sialic acid by platelet derived sialidases promotes auto-antibody binding. This part of the project will allow us to gain more insight into the mechanism of immune thrombocytopenia, especially the role of sialic acid in binding of autoantibodies, thereby creating better treatment options for this disease.
The project is a collaboration between the department of Transfusion Medicine of Sanquin Blood Supply Rotterdam, the department of Hematology of the Erasmus MC Rotterdam, and Department of Plasma Proteins of Sanquin Research Amsterdam. Erasmus MC is an internationally recognized center for high-quality, compassionate care, highly rated transfer of knowledge and high-quality knowledge development in the fields of illness and health. Sanquin performs basic, applied, and clinically oriented research in the field of blood transfusion research. Research activities will take place at both the Erasmus MC and Sanquin Research.
We are looking for:
We are looking for a highly motivated PhD student who will is interested to participate in our search for a better understanding of platelet storage and function. We are looking for a candidate with an academic background who has received excellent scientific training in molecular and cellular biology, preferably with experience with flow cytometry and mass spectrometry.
- we offer a full-time PhD position in an enthusiastic and challenging work environment;
- the successful candidate will be employed as a PhD student for a period of 4 years;
- salary and employment conditions are in accordance with CAO Sanquin (Collective Terms of Agreement);
- a 36-hour-week;
- working hours will be determined by mutual agreement;
- reimbursement of travel expenses in accordance with CAO;
- 8,33% year-end;
- 201 vacation hours with full time employment.
For information regarding this vacancy, please contact Prof. dr. J. Voorberg, telephone: (+31)(020-5123120)
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