Vacature PhD student, OIO, depts of Immunopathology and Hematopoiesis, Amsterdam
Sanquin Bloedvoorziening voorziet in de behoefte aan bloed en bloedproducten in Nederland. In feite staan wij tussen donor en patiënt. Om deze verantwoordelijke taak goed te kunnen blijven vervullen, zijn we altijd op zoek naar betrokken en gemotiveerd talent. Je zal bijdragen aan een unieke organisatie die een internationale voortrekkersrol vervult dankzij de combinatie van medische, farmaceutische en wetenschappelijke kennis in één innovatieve onderneming. Sanquin Bloedvoorziening is op zoek naar een:
PhD student, OIO, depts of Immunopathology and Hematopoiesis, Amsterdam
fulltime (36 uur) | MK 19-14 EXTEW2
Cancer Immunotherapy is one of the newest treatments of cancer, highlighted as the #breakthrough of the year 2013# by the journal Science. One promising form of immunotherapy involves treatment of patients with in vitro expanded T cells isolated from their own primary tumors (Tumor-Infiltrating Lymphocytes or TIL). During expansion however, T cells mostly differentiate into a short-lived phenotype limiting their long-term therapeutic effectiveness. T cell differentiation is known to be driven by external signals that determine their final fate, but only few of these have been identified. In this project we aim to discover novel signals that can skew T cell differentiation to long-lived phenotypes with stem cell properties. To this end, we will generate a unique human secretome library allowing high-throughput screening to identify novel proteins of interest. The activity of found proteins will subsequently be characterized both biochemically and genetically. Eventually, new differentiation regimens will be validated on T cells derived from primary tumor samples obtained in close collaboration with the Antoni van Leeuwenhoek hospital.
This project is a joint effort from the departments of Immunopathology and Hematopoiesis and the Laboratory for Cell Therapy within the Division Research, in collaboration with medical and research experts from the Antoni van Leeuwenhoek hospital. The research is embedded in the departments of Immunopathology and Hematopoiesis, two multidisciplinary departments with strong backgrounds in immunology, molecular biology and high throughput techniques. Sanquin provides a lively, internationally oriented, scientific environment with excellent facilities (flow cytometry, confocal microscopy, mass spectrometry, and sequencing).
We are looking for:
We invite highly motivated individuals with a degree in Biomedical Sciences to apply for this position. We are looking for a responsible, accurate and team-oriented candidate with good communication skills in spoken and written English.
- salary and employment conditions are in accordance with CAO Sanquin (Collective Terms of Agreement);
- a temporary appointment for a period of 4 years;
- a 36-hour-week;
- working hours will be determined by mutual agreement;
- reimbursement of travel expenses in accordance with CAO;
- 8,33% year-end;
- 201 vacation hours with full time employment.
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