Post-doc, Department Hematopoiesis
We are looking for a postdoc to study molecular mechanisms by which extracellular vesicles are derived from the bone-marrow niche cells promote ex vivo expansion of cord blood-derived hematopoietic stem cells (HSC). The research will be performed in close collaboration between Sanquin and the departments of Hematology and Internal Medicine of the Erasmus MC.
Bone marrow niche cells, including osteoblasts and mesenchymal stromal cells, play an important role in the orchestration of hematopoiesis. Newly uncovered means of intercellular communication involves extracellular vesicles (EV). EV can mediate cell-to-cell communication via the transfer of bioactive lipids, proteins, mRNAs, non-coding RNAs and miRNAs that regulate cell fate of EV-targeted cells. Preliminary results indicate that human osteoblast-derived EV promote the ex vivo growth factor-driven expansion of HSC. Proteomic and RNA-seq analysis revealed their protein- and miRNA content. Human MSC-derived EV modulate immune response, and may stimulate HSC expansion as well. This project aims to identify novel components in human bone-marrow niche cell-derived EVs that have the potential to promote strong ex vivo HSC expansion and to develop a GMP-compliant ex vivo expansion protocol for HSC.
Where you will work:
Within the Department Hematopoiesis, the group of Dr. C. Voermans (Stem cell research) investigates homing and support of hematopoietic stem cells and mesenchymal stromal cells, as well as the molecular mechanisms that control expansion and differentiation of both cell types.
We are looking for:
Candidates should have an academic background and completed their PhD, with experience in cellular or molecular biology and interest in translational research. We are looking for an independent, highly motivated candidate with a collaborative nature, a strong affinity for multidisciplinary research and the capacity to write and communicate fluently in English. Furthermore you are accurate, enterprising and persevering.
- pay and working conditions conform CAO Sanquin;
- working hours are fixed by mutual agreement;
- a temporary assignment for a period of 3 years;
- a 36-hour work week;
- 8,33% year-end premium, this means in a calendar year a full thirteenth month;
- at full-time employment (36 hours) 201 vacations hours;
- personal life phase budget of at least 57 hours at full-time employment;
- reimbursement of travel expenses.
Interesse in de functie van Post-Doc bij Sanquin in Amsterdam?
Reageer nu met je CV en motivatie via de bovenstaande "solliciteer direct" button.
Information can be obtained from Dr. C. Voermans, group leader within the department of Hematopoiesis, telephone number 06-10921583.
Sanquin is not accepting unsolicited assistance from agencies for this job. CVs sent (in whatever form) by agencies to any Sanquin employee without an official search request by the Sanquin HR department are considered public information. No compensation will be paid in the event a candidate hired by Sanquin as a result of unsolicited forwarding of CVs.