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Vacature Postdoc: Novel mouse models to study regulation of lipid metabolism by the UPS

The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It's not possible' or 'It won't work anyway'. That is the AMC mentality.

Postdoc: Novel mouse models to study regulation of lipid metabolism by the UPS

AMC Medical Research supports financiers, project leaders and coworkers on clear, effective and Legal execution of medical research within the Academic Medical Center (AMC) third parties financed. It contains advising and guidance on project preparations, project services and staffing management.

Medical Biochemistry.

Job Description:

Cholesterol metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of cholesterol does not increase to toxic levels and that sufficient cholesterol is available for processes requiring it. Disruption of this balance is at the center of several pathological conditions in humans, most notably cardiovascular disease. Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism and the specific role of the ubiquitin system herein (e.g Zelcer et al., Science 2009; Zelcer et al. MCB 2014; Sharpe et al. TIBS 2014; Loregger et al. MCB 2015; Nelson et al. Circ Res 2016). We have recently identified several novel components of the ubiquitin proteasomal system that are involved in regulating key lipid-dependent cellular processes. As part of an ERC project we have developed several new conditional mouse models of E3 ubiquitin ligases implicated in lipid metabolism. As such, the central goal of this ERC-supported project is to elucidate the role of these genes in lipid metabolism and atherosclerosis at the mechanistic level as well as in vivo in mice.

Job Requirements:

We are looking for a highly motivated scientist with a PhD in Medical Biology, Life Sciences, Biochemistry or a related field with a proven track record and affinity for conducting metabolic studies in mice. The candidate should have good command of oral and written English. Excellent communication skills and the ability to work within an international research group are essential.

Salary and Benefits:

Working at AMC means working in an inspiring and professional environment in which developing one`s talents and skills is encouraged. We offer a salary in line with the Collective Labour Agreement for University Medical Centres in the Netherlands (CAO UMC) with a range of added fringe benefits, such as an annual bonus of 8.3 %, holiday allowance, collective discounted rates for a number of insurances, an attractive bicycle scheme and/or public transport allowance and free parking! The maximum gross full-time monthly salary for this position, depending on qualifications and experience, is € 4.152,- (scale 10). The position is initially for 2 years (with ample possibility for extension).

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