Post doc – Phosphoproteomics of blood platelets activation
Job description Post Doc Amsterdam:
Activation of blood platelets is essential for blood clot formation. Blood platelets express a variety of receptors that can be activated by multiple ligands resulting in platelet activation, shape change and aggregation. The signaling pathways downstream of these receptors have remained largely unexplored. The current project aims to unravel which signaling pathways are triggered upon platelet activation by various agonists using mass spectrometry-based phosphoproteomics. This approach has recently been used successfully to dissect thrombin-mediated signaling events in endothelial cells (van den Biggelaar et al. Blood 2014). The same technology will also be used to better define the aberrant functional and signaling properties of a cohort of patients with congenital platelet disorders. The findings will be combined with next generation sequencing approaches to define signaling networks crucial for platelet function. Altogether, this will provide us with a roadmap of early signaling events that contribute to platelet (dys)function. The information arising from these studies will be integrated in parallel studies on the in vitro production of platelets from megakaryocytes.
You will work in a multidisciplinary international team that focuses on the biology of blood platelets coagulation proteins and cells of the haemostatic system. This team is embedded in the Department of Plasma Proteins, where 25-30 fellow colleagues (post-docs, PhD students and technicians) are studying various aspects of bleeding disorders. The department’s research program benefits from the excellent research facilities at Sanquin, which include the newest technology for molecular cell biology, protein engineering and mass spectrometry.
Where you will work as a Post Doc:
Sanquin Research performs basic, applied, and clinically oriented research in the field of blood and blood transfusion. Our research is focussed on haematology, blood coagulation, immunology, cellular therapies and donor studies. Sanquin offers an international, competitive, multidisciplinary research environment with state-of-the-art facilities. With over 200 colleagues, our focus is both on fundamental and applied research. We are interested in meeting ambitious researchers with training in life sciences, cell biology, biochemistry, or health sciences.
Sanquin Blood Supply Foundation is responsible for the blood supply in the Netherlands, and is affiliated to the University of Amsterdam and other universities in the Netherlands.
We are looking for:
We are specifically interested in candidates who hold a PhD in Analytical Chemistry, Cell Biology, Molecular Sciences, Biochemistry or a related field. Candidates must have strong intellectual and experimental skills, in addition to experience/interest in mass spectrometry, bioinformatics, biochemistry and molecular biology.
- salary and employment conditions are in accordance with CAO Sanquin (Collective Terms of Agreement);
- a temporary appointment for a period of 3 years;
- a 36-hour-week;
- working hours will be determined by mutual agreement;
- reimbursement of travel expenses in accordance with CAO;
- 8,33% year-end;
- 201 vacation hours with full time employment.
Interesse in de functie Post Doc bij Sanquin in Amsterdam?
Reageer voor 26 februari a.s. met je CV en motivatie via de bovenstaande "solliciteer direct" button.
For further information, please contact Dr. Maartje van den Biggelaar (tel. +31-20-5121289).
Canvassing in response to this advertisement is not welcome.