Vacature Postdoc The microbiota in sepsis
The AMC is more than just a hospital. It is a world in which patient care, research and education are integrated, and in which people are always central. It is an academic world full of possibilities for talented individuals that are looking for a place where they can excel. Thinking big, daring to dream, cooperating internationally. And never letting yourself be put off by ‘It's not possible' or 'It won't work anyway'. That is the AMC mentality.
As a temporary researcher you will be contracted by AMC Medical Research. The related AMC department which you will service is physically your workplace. Working directly with your supervisor and your colleagues within your expertise or institution will be the base for your content job, your daily management and your working environment. The AMC Medical Research BV general employment conditions are largely similar to those of Academic Medical Center. The Center for Experimental and Molecular Medicine (CEMM) is a laboratory within the AMC which is fully devoted to interdisciplinary fundamental and clinical research of a variety of common diseases including infectious diseases. It is the ambition of CEMM to facilitate translational science in the broadest of terms, maintaining strong ties with clinical departments and providing an optimal infrastructure and multidisciplinary environment for the scientific flourish of our research groups. The staff of the Center consists of a well-balanced mixture of clinical and fundamental scientists. Currently, CEMM houses 80 researchers, the majority of which PhD students. The Translational Infectious Diseases Group: Principal Investigator: W. J. Wiersinga, his group consists of 6 PhD students members and is embedded in the larger research environment of prof. dr. T. van der Poll in which > 20 PhD students, postdocs, technicians are working. In important aspect of the project is the daily supervision of several PhD students.
This project will focus on the role of the gut and lung microbiota in pneumonia and sepsis. The intestinal microbiota has emerged as a key defense system by local support of mucosal immunity as well as proposed modulatory effects on systemic immunity. Sepsis is the consequence of a deregulated host response to a severe infection. We recently completed human and murine studies that demonstrate a potential protective role of the microbiota in the host response against systemic bacterial infection. Now the aim of this project is to evaluate the mechanistic and functional role of both the gut and lung microbiota in sepsis and develop novel treatment options which will be evaluated in murine models of sepsis. This project will make use of patient samples, a human model in which volunteers are instilled with LPS and murine models of bacterial pneumonia. Experience with microbiota research, CRISPR-Cas9 and functional genomics is preferable. An innovative, pro-active and ‘out-of-the box' way of thinking is of importance in this fast moving research field. The project is sponsored by the Netherlands Organisation of Scientific Research (NWO) by a VIDI grant to the group leader (W. J. Wiersinga).
We are looking for a post-doctoral researcher with a completed PhD in Biomedical Sciences with research experience in Immunology, Microbiota research, preferably functional genomics or equivalent.
Salary and Benefits
Working at AMC means working in an inspiring and professional environment in which developing one`s talents and skills is encouraged. We offer a salary in line with the Collective Labour Agreement for University Medical Centres in the Netherlands (CAO UMC) with a range of added fringe benefits, such as an annual bonus of 8.3 %, holiday allowance, collective discounted rates for a number of insurances, an attractive bicycle scheme and/or public transport allowance and free parking! The maximum gross full-time monthly salary for this position, depending on qualifications and experience, is € 4.152,- (scale 10). The position is for a period of 3 years, preferably starting November 2016.
If you wish to apply for this position, click on the ‘online application' button. For more information, please contact Dr. W. Joost Wiersinga, internist-infectioloog, Phone: +31 20 566911,1 Email: firstname.lastname@example.org or H.M. Winkelhuijzen, Stafadviseur, Phone: +31 20 566 59 10, Email: email@example.com
We are looking forward to meeting you!
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